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While doxylamine/pyridoxine is the only FDA-approved medication for morning sicknessdoctors continue to write off-label prescriptions for other medicationsFirst-line alternatives include antihistamines diphenhydramine and meclizinewhich were deemed Pregnancy Risk Category Blike Zofran.

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As the class name suggestsZofran targets 5-HT3 receptors in the bodyThese receptors exist in both the central and peripheral nervous systemand when joined with a neurotransmitter called serotoninthey can cause nausea and vomiting.

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