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Celecoxib is a potent inhibitor of prostaglandin synthesis in vitroCelecoxib concentrations reached during therapy have produced in vivo effectsProstaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal modelsProstaglandins are mediators of inflammationSince celecoxib is an inhibitor of prostaglandin synthesisits mode of action may be due to a decrease of prostaglandins in peripheral tissues.

The pharmacological activity of CELEBREX in reducing inflammationand possibly fevermay diminish the utility of diagnostic signs in detecting infections.

Taking Celebrex during the last 3 months of pregnancy may harm the unborn babyTell your doctor if you are pregnant or plan to become pregnant while using Celebrex.

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celebrex, generic drug name celecoxib, is a cox-2 selective.