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Donpzil hydochloid is both xctd in th uin intact and mtabolisd by th cytochom P450 systm tmultipl mtabolits, not all which hav bn idntiid. ollowing administation a singl 5 mg dos 14 C-lablld donpzil hydochloid, plasma adioactivity, xpssd as a pcnt th administd dos, was psnt pimaily as intact donpzil hydochloid (30%), 6-O-dsmthyl donpzil (11% – only mtabolit that xhibits activity simila tdonpzil hydochloid), donpzil-cis-N-oxid (9%), 5-O-dsmthyl donpzil (7%) and th glucuonid conjugat 5-O-dsmthyl donpzil (3%). Appoximatly 57% th total administd adioactivity was covd om th uin (17% as unchangd donpzil), and 14.5% was covd om th acs, suggsting biotansomation and uinay xction as th pimay outs limination. Th is nvidnc tsuggst ntohpatic ciculation donpzil hydochloid and/any its mtabolits.
Donpzil can caus sid cts that may impai you thinking actions. B caul i you div danything that quis you tb awak and alt.
This list is not complt and th may b oth dugs that can intact with donpzil. Tll you doctabout all th psciption and ov-th-count mdications you us. This includs vitamins, minals, hbal poducts, and dugs pscibd by oth doctos. Dnot stat using a nw mdication without tlling you docto.
Whil th dugs a only appovd ttat Alzhim’s, in Canada th dugs can b accssd by popl with mild cognitiv impaimnt whn thy hav spcial wittn authoization.
Donpzil has minmodat inlunc on th ability tdiv and us machins.
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