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In paediatric patients1 month to less than 4 years of agelevetiracetam efficacy was established in a double-blindplacebo-controlled studywhich included 116 patients and had a treatment duration of 5 daysIn this studypatients were prescribed 20 mg/kg25 mg/kg40 mg/kg or 50 mg/kg daily dose of oral solution based on their age titration scheduleA dose of 20 mg/kg/day titrating to 40 mg/kg/day for infants one month to less than six months and a dose of 25 mg/kg/day titrating to 50 mg/kg/day for infants and children 6 months to less than 4 years oldwas use in this studyThe total daily dose was administered twice daily.
KEPPRA oral solution contains 100 mg of levetiracetam per mLInactive ingredientsammonium glycyrrhizinatecitric acid monohydrateglycerinmaltitol solutionmethylparabenpotassium acesulfamepropylparabenpurified watersodium citrate dihydrate and natural and artificial flavor.
No dose adjustment is needed in patients with mild to moderate hepatic impairmentIn patients with severe hepatic impairmentthe creatinine clearance may underestimate the renal insufficiencyTherefore a 50reduction of the daily maintenance dose is recommended when the creatinine clearance is 2
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keppra may cause coordination difficulties.
