Study 2 was a double-blind, placebo-controlled, crossover study conducted at 62 centers in europe comparing keppra 1000 mg day n 106 , keppra 2000 mg day n 105 , and placebo n 111 given in equally divided doses twice daily.
Information about Keppra.
Keppra was as effective as carbamazepine in keeping patients free of seizures when taken on its own for partial onset seizuresIn both groups73of the patients experienced no seizures for six months once on an adequate doseAs an add-on treatmentKeppra was more effective than placebo:
The extent of absorption of levetiracetam was not altered by foodbut the rate of absorption was slightly reduced.
The precise mechanism(sby which levetiracetam exerts its antiepileptic effect is unknownThe antiepileptic activity of levetiracetam was assessed in a number of animal models of epileptic seizuresLevetiracetam did not inhibit single seizures induced by maximal stimulation with electrical current or different chemoconvulsants and showed only minimal activity in submaximal stimulation and in threshold testsProtection was observedhoweveragainst secondarily generalized activity from focal seizures induced by pilocarpine and kainic acidtwo chemoconvulsants that induce seizures that mimic some features of human complex partial seizures with secondary generalizationLevetiracetam also displayed inhibitory properties in the kindling model in ratsanother model of human complex partial seizuresboth during kindling development and in the fully kindled stateThe predictive value of these animal models for specific types of human epilepsy is uncertain.
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4 of keppra-treated patients experienced coordination difficulties, reported as either ataxia, abnormal gait, or incoordination compared to 1.
