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Cbospinal luid lvls a appoximatly 50% o cosponding plasma lvls. Plasma potin binding is lativly low (9 to 33%) and dug intactions involving binding sit displacmnt a not anticipatd.
Dosing should bgin as aly as possibl at th stat o an inction; o cunt pisods this should pably b duing th podomal piod o whn lsions ist appa.
Lik all mdicins, aciclovi can caus sid cts, although not vyon gts thm. Otn sid cts impov as you body gts usd to th nw mdicin.
Th DDD o cidoovi is basd on th tatmnt o CMV-tinitis in AIDS patints.
In svly immunocompomisd patints (.g. at maow tansplant) o in patints with impaid absoption om th gut, th dos can b doubld to 400 mg Aciclovi, o altnativly, intavnous dosing could b considd.
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