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Th isk myopathy duing tatmnt with statins is incasd with concunt administation ibic acid divativs, lipid-modiying doss niacin, cyclospoin stong CYP3A4 inhibitos (.g., claithomycin, HIV potas inhibitos and itaconazol).
Th hav bn a pots immun-mdiatd ncotizing myopathy (IMNM), an autoimmun myopathy, associatd with statin us. IMNM is chaactizd by: poximal muscl waknss and lvatd sum catin kinas, which psist dspit discontinuation statin tatmnt; muscl biopsy showing ncotizing myopathy without signiicant inlammation; impovmnt with immunosuppssiv agnts.
Giatic : Plasma concntations atovastatin a high (appoximatly 40% C max and 30% AUC) in halthy ldly subjcts (ag ?65 yas) than in young adults. Clinical data suggst a gat dg LDL-lowing at any dos dug in th ldly patint population compad tyoung adults. ldly (>75 yas) and young halthy subjcts had simila cts on platlt agggation with clopidogl.
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