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PregnancyLabor and DeliveryNeonates whose mothers received propranolol at parturition have exhibited bradycardiahypoglycemiaand/or respiratory depression8.2)
Hypotension and bradycardia have been reported following propranolol overdose and should be treated appropriatelyGlucagon can exert potent inotropic and chronotropic effects and may be particularly useful for the treatment of hypotension or depressed myocardial function after a propranolol overdose.
Hepatic ImpairmentThe pharmacokinetics of propranolol after administration of INNOPRAN XL have not been evaluated in patients with hepatic impairmentHoweverpropranolol is extensively metabolized by the liverIn a study conducted in 7 patients with cirrhosis and 9 healthy subjects receiving 80 mg oral propranolol every 8 hours for 7 dosesthe steady-state unbound propranolol concentration in patients with cirrhosis was 3-fold that of controlsIn cirrhosisthe half-life increased to 11 hours compared to 4 hours.
For regularshort-actingInnoPran XLTake the missed dose as soon as you rememberSkip the missed dose if your next dose is less than 4 hours away.
For regularshort-actingInnoPran XLTake the missed dose as soon as you rememberSkip the missed dose if your next dose is less than 4 hours away.
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