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Pregnancy Category CPregnancy category D from 30 weeks of gestation onward.
Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusionIn these patientsadministration of an NSAID may cause a dose-dependent reduction in prostaglandin formation andsecondarilyin renal blood flowwhich may precipitate overt renal decompensationPatients at greatest risk of this reaction are those with impaired renal functiondehydrationhypovolemiaheart failureliver dysfunctionthose taking diureticsACE-inhibitors or the ARBsand the elderlyDiscontinuation of NSAID therapy is usually followed by recovery to the pretreatment state.
Inform patients of the signs of an anaphylactic reactione.gdifficulty breathingswelling of the face or throatInstruct patients to seek immediate emergency help if these occursee CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS
Taking Celebrex during the last 3 months of pregnancy may harm the unborn babyTell your doctor if you are pregnant or plan to become pregnant while using Celebrex.
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