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Adverse effects of loop diuretics unrelated to the diuretic efficacy are rareand most adverse effects are due to abnormalities of fluid and electrolyte balanceHoweverloop diuretics can induce ototoxicity.
Deeb et al2013Disrupted Clhomeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited statesEur J Neurosci 38 2453 PMID23627375.
Angelantonio et al2014A role for intracellular zinc in glioma alteration of neuronal chloride equilibriumCell Death Dis 5 e1501 PMID25356870.
Approximately 65of furosemide is excreted unchanged in the urineand the remainder is conjugated to glucuronic acid in the kidneyAccordinglyin patients with renalbut not liverdiseasethe elimination half-life of furosemide is prolongedThe elimination half-life is short.
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