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Although reported clinical experience has not identified differences in responses between elderly and younger patients, effects of aging might be expected to increase some risks associated with isotretinoin therapy see warnings and precautions .

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Wash your hands before applying this medicationGently clean the affected skin with a mild or soapless cleanser and pat dryUse your fingertips to apply a small amount of medicationabout the size of a peain a thin layerusually once daily at bedtime or as directed by your doctorA gauze pad or cotton swab can be used to apply the liquidFor some preparationsyou should wait 20-30 minutes after cleaning your face before applying this medicationConsult the label directionsthe Patient Information Leafletor your pharmacist if you have any questions.

Nursing MothersIt is not known whether topical hydroquinone is absorbed or excreted in human milkCaution is advised when topical hydroquinone is used by a nursing mother.

This list is not complete and there may be other drugs that can affect tretinoin topicalTell your doctor about all the prescription and over-the-counter medications you useThis includes vitaminsmineralsherbal productsand drugs prescribed by other doctorsDo not start using a new medication without telling your doctor.

Tretinoin is a derivative of vitamin AIt is used on the skintopicallyin the treatment of mild to moderate acne and on skin that has been damaged by excessive exposure to the sunTretinoin irritates the skin and causes the cells of the skin to growdivideand die more rapidlyincreasing the turnover of cellsThe number of layers of cells in the skin actually is reducedIn patients with acnenew cells replace the cells of existing pimplesand the rapid turnover of cells prevents new pimples from formingBy a similar mechanismtretinoin can reduce some wrinklesareas of darkened skinhyperpigmentationand rough areas of skinall of which occur in sun-damaged skinIn patients with sun-damaged skinimprovements in the skin usually are seen within the first 3 to 4 weeks of treatmentBrown spots begin to fade after six to eight weeksWrinkles decrease or disappear after three to six monthsFollowing application to the skina minimal amount of drug is absorbed into the bodyThe FDA approved topical tretinoin in 1971.

Tell your doctor immediately if you experienceblisteringcrustingsevere burning/swelling of the skineye redness and wateringconjunctivitiseyelid swellingskin discoloration.

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how to apply tretinoin cream to the affected area.