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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Inform caregivers to monitor for gastrointestinal adverse reactions and to inform the physician if they occurIt is critical to inform caregivers that if therapy has been interrupted for more than 3 days because of intolerancethe next dose should not be administered without contacting the physician regarding proper retitration.

Figure 6 is a histogram of the frequency distribution of CIBIC-Plus scores attained by patients assigned to each of the 3 treatment groups who completed 26 weeks of treatmentThe mean EXELON-placebo differences for these groups of patients for the mean rating of change from baseline were 0.14 units and 0.41 units for 1 mg to 4 mg and 6 mg to 12 mg of EXELONrespectivelyThe mean ratings for the 6 mg to 12 mg per day group were statistically significantly superior to placeboThe comparison of the mean ratings for the 1 mg to 4 mg per day group and placebo group was not statistically significant.

Exelonrivastigmineimproves the function of nerve cells in the brainIt works by preventing the breakdown of a chemical that is important for the processes of memorythinkingand reasoningPeople with dementia usually have lower levels of this chemical.

Caregivers should be advised of the high incidence of nausea and vomiting associated with the use of the drug along with the possibility of anorexia and weight lossCaregivers should be encouraged to monitor for these adverse events and inform the physician if they occurIt is critical to inform caregivers that if therapy has been interrupted for more than several daysthe next dose should not be administered until they have discussed this with the physiciansee WARNINGS AND PRECAUTIONS

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