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Famciclovir is the prodrug of penciclovirIt is an orally administered drug and essentially all is converted to the active antiviral compoundpenciclovirPenciclovir has strong inhibitory effects against herpes simplex virus types 1 and 2as well as varicella zosterTyring and coworkers 252 carried out a study of 454 patients with ophthalmic zoster of the trigeminal nerveIn this study patient were randomized to either oral famciclovir 500 mg three times daily or oral aciclovir 800 mg five times a day for 7 daysThe two drugs appeared to demonstrate similar efficacy and famciclovir was well toleratedBecause the drug is cleared in the kidneydosage must be appropriately reduced for patients with reduced renal functionThere are no well-controlled studies in pregnant womenAlthough testicular toxicity was noted in rodentsstudies in normal males did not show a change in sperm count or motilityUrticariahallucinationsand confusion have been reported by patients taking the drug.
First episode of genital herpes250 mg three times daily for five daysInitiation of treatment is recommended as soon as possible after a diagnosis of first episode of genital herpes.
For pregnant womenFamciclovir is a category B pregnancy drugThat means two things:
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