For headache and nausea metoclopramide reglan or prochlorperazine compazine .
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Extrapyramidal symptomsmanifested primarily as acute dystonic reactionsoccur in approximately 1 in 500 patients treated with the usual adult dosages of 30 to 40 mg/day of metoclopramideThese usually are seen during the first 24 to 48 hours of treatment with metoclopramideoccur more frequently in pediatric patients and adult patients less than 30 years of age and are even more frequent at higher dosesThese symptoms may include involuntary movements of limbs and facial grimacingtorticollisoculogyric crisisrhythmic protrusion of tonguebulbar type of speechtrismusor dystonic reactions resembling tetanusRarelydystonic reactions may present as stridor and dyspneapossibly due to laryngospasmIf these symptoms should occurinject 50 mg diphenhydramine hydrochloride intramuscularlyand they usually will subsideBenztropine mesylate1 to 2 mg intramuscularlymay also be used to reverse these reactions.
A patient Medication Guide is available for Reglan InjectionThe prescriber or health professional should instruct patientstheir familiesand their caregivers to read the Medication Guide and should assist them in understanding its contentsPatients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may haveRefer to accompanying Medication Guide.
Giving a promotility drug such as metoclopramide theoretically could put increased pressure on suture lines following a gut anastomosis or closureThis possibility should be considered and weighed when deciding whether to use metoclopramide or nasogastric suction in the prevention of postoperative nausea and vomiting.
Intravenous infusions should be made slowly over a period of not less than 15 minutes30 minutes before beginning cancer chemotherapy and repeated every 2 hours for two dosesthen every 3 hours for three doses.
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