The medication with the active substance called roxithromycin, is a semi synthetic antibiotic, a derivative of erythromycin.
Information about Roxithromycin.
ManagementThe concurrent administration of roxithromycin and an ergot derivative is contraindicated.
The optimal duration of antimicrobial treatment for late forms of Lyme neuroborreliosis is unclearBecause as many as 10of patients who improve initially following 2 weeks of therapy may have a relapseLogigian and Steere1992duration of IV therapy is sometimes extended to 4 weeksA randomizedprospective clinical trial showed higher treatment failures in patients treated for 14 days5/80than in patients treated for 28 days0/63P0.07Dattwyler et al2005There is no evidence that treatment for longer than 4 weeks results in greater improvementWahlberg et al1994Sigal1995Wormser et al2006In factprolonged IV treatment with ceftriaxone can be dangerousresulting in biliary complicationsCenters for Disease Control and Prevention1993or even lead to death or serious morbidity related to catheter-associated bloodstream infectionPatel et al2000Corticosteroids are not recommended in patients with Lyme neuroborreliosisAlthough early reports suggested that steroid therapy resolved radicular pain in meningopolyneuritissubsequent controlled trials showed that the pain resolved almost as quickly with antimicrobial treatment alonePfister et al1988Furthermoresteroid use has been associated with subsequent antimicrobial treatment failure during late disease in humansDattwyler et al1988and worsening of disease in experimental animalsCadavid et al2000Straubinger et al2000
Take roxithromycin at the same time each dayRoxithromycin is best taken on an empty stomachabout 15 minutes before foodIf it makes you feel sickthen take it with foodKeep taking roxithromycin until you finish all the tabletsfor as long as your doctor or pharmacist tells you toDo not stop taking roxithromycineven if you feel better after a few daysunless your doctor tells you toIf you forget to take roxithromycintake it as soon as you rememberButif it is nearly time for your next dosejust take the next dose at the right timeDo not take double the dose.
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index medicus and the passport cd-rom database roussel uclaf were searched to identify published clinical studies with roxithromycin.
