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Sildenafil has also been shown to induce a state of peripheral analgesia via activation of the NO/cGMP signaling pathway in animalsJain et al 2001This effect could be instrumental in alleviating the penile hypersensivity that is reported in some patients with PE and may in turn mimic the success of topical anesthetics in the treatment of some PE patientsBerkovitch et al 1995
Premature ejaculationPEis the most common male sexual disorderestimated to affect up to 30of menOver the past one or two decadesclinical investigators have participated in an increasing number of studies that are helping in our understanding of PEwhich will undoubtedly facilitate future treatmentsApart from a number of behavioral approachesthe treatment of PE consists of primarily off-label use of oral selective serotonin reuptake inhibitorsSSRIsvia either on-demand or daily deliveryHowevervarious undesirable side-effects of these medications have led researchers to search for and develop new therapeutic approaches for PEDapoxetine is a short-acting SSRI developed specifically for the treatment of PEEarly trials with dapoxetine have documented successful outcomes without serious shortor long-term side-effectsThis review addresses the definitionclassificationdiagnosisphysiologyand neurobiopathology of PEand evaluates therapeutic strategies with novel treatments for PE.
1 Department of UrologySisli Etfal Training and Research HospitalIstanbulTurkey.
Dapoxetinea novel selective serotonin transport inhibitor for the treatment of premature ejaculation.
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