Chloramphenicol is a broad spectrum antibiotic with bacteriostatic activity and is effective against a wide range of gram-negative and gram-positive.
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chloramphenicol is also not recommended to be given in pregnant or lactating animals due to its ability to cross the placenta and passed in breast milk.
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although before 1970 a few sporadic isolations of chloramphenicol-resistant salmonella typhi had been reported from chloramphenicol-resistant strain was that which occurred in mexico in 1972.
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the expression of 70 genes encoding transport binding proteins changed on exposure to chloramphenicol, including genes encoding permeases, abc transporters and transport proteins of carbohydrates, cations and anions.
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a short anecdotal report of long term use of oxacillin an anti-staphylococcal antibiotic available since 1962 in 15 patients with cf many of whom were receiving other antibiotics mainly chloramphenicol.
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when the national committee for clinical laboratory standards mic interpretive breakpoints for haemophilus influenzae were applied, percentages of strains found to be susceptible to selected oral antimicrobial agents were as follows azithromycin, clarithromycin, and erythromycin, 100 ; tetracycline and chloramphenicol, 100 ; amoxicillin-clavulanate, 100 ; cefixime, 99.
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